Description
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.
The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain.
Notably, the intracellular domain of phatases.
The extracellular domain sequence of human and mouse CD112R have 65.3% similarity.
CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals